Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
No Results found.
Please try different keywords.
When reconstituting peptides for injection, the choice between Bacteriostatic Water (BW/BAC) and Sterile Saline (NSS – Normal Saline Solution) plays a critical role in stability, safety, and overall usability.
Composition:
Contains 0.9% benzyl alcohol, which acts as a preservative to inhibit bacterial growth.
Advantages:
- Extends shelf life of reconstituted peptides beyond 28 days (if refrigerated and handled cleanly).
- Suitable for multi-dose vials and protocols lasting several weeks.
Limitations:
- Benzyl alcohol may interfere with solubility or stability of longer, delicate peptides (though uncommon with shorter ones like BPC-157 or TB-500).
- Can cause cloudiness, viscosity changes, or reduced stability.
- Potential for sensitivity or allergic reactions at the injection site (redness, rash, itching).
- Not recommended for infants, pregnancy, or prolonged use due to possible toxicity.
Composition:
Preservative-free solution, filtered and sterilized, isotonic (same salt concentration as the human body).
Advantages:
- Provides superior biocompatibility, minimizing irritation at the injection site.
- Maintains peptide stability and lifespan without preservative-related risks.
- Isotonicity prevents hemolysis (cell swelling/bursting) that can occur with sterile water alone.
Limitations:
- Once opened, sterility is no longer guaranteed.
- Best used within 14 days after reconstitution.
- Requires strict aseptic technique to avoid contamination.
Peptide Stability:
Longer peptides are more prone to destabilization in BW due to benzyl alcohol. NSS is generally safer for maintaining integrity.
Injection Site Reactions:
NSS is gentler because it matches body fluid tonicity, whereas BW may cause irritation or reactions in sensitive individuals.
Storage & Handling:
- Always store reconstituted peptides in a refrigerator at below 4°C, but never freeze.
- Keep vials in a separate, sealed, clean container (preferably disinfected with methanol).
- Wipe vial tops with an alcohol swab before each injection.
Usage Timeline:
- With BW: Suitable for extended use beyond 28 days if stable.
- With NSS: Use within dosing guidelines and ideally within a month.
For most peptides and long-term stability, Normal Saline Solution (NSS) is the preferred choice. It avoids preservative-related complications, ensures isotonicity, and minimizes injection site irritation. Bacteriostatic water can still be useful for multi-dose protocols but carries more risks for certain peptides and individuals.